Development of a Physiologically Based Toxicokinetic Model for Human Exposure Risk Assessment of Methylene Diphenyl Diisocyanate (MDI)
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| Title: | Development of a Physiologically Based Toxicokinetic Model for Human Exposure Risk Assessment of Methylene Diphenyl Diisocyanate (MDI) |
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استنادات
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| Author(s): | Mozaffari, S., Bayatian, M., Hsieh, N.-H., (...), Ashrafi, K., Shahtaheri, S.J. | |
| Published/Type: | 2023 / Original Article | |
| Journal: | Iran Occupational Health, 20(1), pp. 1-17 | |
| Abstract:
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Background and aims: Introduction: This study aims to develop a physiologically based toxicokinetic (PBTK) model for human systemic exposure assessment of methylene diisocyanate (MDI) and prediction of its urinary metabolites, given the lack of a developed model. Methods: A PBTK model was constructed with parameter uncertainty and variability to assess potential exposure to MDI. The model was calibrated using Bayesian analysis via the Markov chain Monte Carlo approach. Exposure reconstruction or... | |
| Collaborations: |  .jpg) |
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| View at: |
https://ioh.iums.ac.ir/browse.php?a_id=3272&sid=1&slc_lang=en |
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